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Index promoters, 101, 102 selection, compensatory selection, 103 positive selection, 103 purifying selection, 103 sequence databases, 104106 silent substitutions, 102 trans mutations, 102, 103 transcription factor-binding sites, 100, 101 transcription factors, 101 Gene expression networks, derivation from DNA microarrays, adjacency matrix calculation, 36, 37 clustering of dynamic parameters, 37 data sources, 36 gene classification, 42, 43, 45 λ-matrix calculation, 36 H High-throughput screening (HTS), see also Virtual screening, automation, 5 compound generation, 5, 6 goals, 375 nuclear magnetic resonance, see Nuclear magnetic resonance target validation in rational drug design, HL7 clinical genomics standards, Genotype model, aims, 143, 144 bioinformatics formats, 149 bone marrow transplantation application, 145 coexistence of HL7 objects and bioinformatics markup, 149, 150 general features, 145, 146, 148, 149 validation, 149 overview, 142, 143 pharmacogenomics model, 151, 153 storyboarding, 150, 151 Homolog, definition, 87 Homology modeling, binding sites, 311, 312, 314 linear models, margin in Forex is preprocessing, 45, 46 singular value decomposition, 47 time-series data, 42 visualization of networks, 37 Gene networks, see Gene expression networks Gene ontology (GO), functional classification applications, 6971 gene product similarity assessment, 71, 72 linking of ontology with expression data, 7275, 77 overview, 6769 prospects for study, 85 term finding in gene sets, FatiGO tool, defining relevant groups of genes, 80, 82, 83 overview, 7779, 84 validation of margin in Forex is genomics results, 79, 80 over- and underrepresented terms, 78, 79 437 statistical framework, 77, 78 Gene to lead concept, see Rational drug design GeneChip, see DNA microarray Genetics Computer Group (GCG), sequence data format, 116, 117, 153 Gleevec, applications, 200 mechanism of action, 200 GO, see Gene ontology GOLD, virtual screening of receptor ligands, 330 GPCRs, see G protein-coupled receptors G protein-coupled receptors (GPCRs), binding sites, 292, 293 signaling, 292 GRID, binding site visualization, 322324 Application of Pathology in Safety Assessment 435 formalin offers the margin in Forex is that the tissue can be left in the formalin solution without becoming too hard.
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